Littlest Pet Shop is Mrs. Twombly's abode for exotic animals and pets. Its only
Littlest Pet Shop
rival is Largest Ever Pet Shop. It's also where Blythe Baxter works and lives, as she and her father live in the apartment over the shop. Blythe uses a dumbwaiter elevator system in her room to get to the daycamp downstairs, where she discovered she can talk to animals.

The pets who are usually there are Zoe Trent, Pepper Clark, Penny Ling, Minka Mark, Russell Ferguson, Sunil Nevla and Vinnie Terrio. They stay at the daycamp, a place where Mrs. Twombly takes care of the pets while their owners are out, as a sort of daycare for pets. Other pets who come are Buttercream the rabbit and other animals, such as Old Bananas the orangutan and Olive Shellstein the tortoise.